C0621

CI−994

≥98% (HPLC), powder

• 동의어(들): 4-Acetylamino-N-(2′-aminophenyl)benzamide, Acetyldinaline, Tacedinaline
• 실험식(Hill 표기법): C₁₅H₁₅N₃O₂
• CAS Number: 112522-64-2
• Molecular Weight: 269.30
• MDL number: MFCD00866266
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329774808
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: off-white
• solubility: DMSO: >10 mg/mL
• 저장 온도: room temp
• SMILES string: CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N
• InChI: 1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
• InChI key: VAZAPHZUAVEOMC-UHFFFAOYSA-N
• 유전자 정보: human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)

설명

애플리케이션

CI-994 has been used:

• as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effects
• as an HDAC inhibitor for screening in SPEL cells
• to study its effects on human myeloid and erythroid progenitors

생화학적/생리학적 작용

CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994.

특징 및 장점

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves