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Merck
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문서

M0300000

Menadione

European Pharmacopoeia (EP) Reference Standard

동의어(들):

2-Methyl-1,4-naphthoquinone, Vitamin K3

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About This Item

실험식(Hill 표기법):
C11H8O2
CAS Number:
Molecular Weight:
172.18
Beilstein:
1908453
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

생물학적 소스

synthetic

Grade

pharmaceutical primary standard

Agency

EP

API family

menadione

형태

solid

제조업체/상표

EDQM

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

105-107 °C (lit.)

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

CC1=CC(=O)c2ccccc2C1=O

InChI

1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3

InChI key

MJVAVZPDRWSRRC-UHFFFAOYSA-N

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일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Menadione, a fat-soluble vitamin, is an antihemorrhagic compound that plays an important role in blood coagulation. It takes part in blood clotting by activating prothrombin, the thrombin precursor.

애플리케이션

Menadione may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry techniques.

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

관련 제품

픽토그램

Exclamation markEnvironment

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

이미 열람한 고객

Spectrophotometric methods for the rapid determination of menadione and menadione sodium bisulphite and their application in pharmaceutical preparations
Nagaraja P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(1), 161-168 (2002)
Menadione
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 13(2), 2998-2998 (2008)
Spectrophotometric determination of menadione and menadione sodium bisulfite in pharmaceutical preparations
Sastry CSP, et al.
International Journal of Pharmaceutics, 39(1-2), 137-140 (1987)
GC-FID and HPLC-DAD methods for the determination of menadione sodium bisulphite directly and by converting menadione sodium bisulphite to menadione in pharmaceutical preparation
Demirkaya-Miloglu F, et al.
The Iranian Journal of Pharmaceutical Research, 13(2), 353-353 (2014)
Y Usui et al.
The American journal of clinical nutrition, 51(5), 846-852 (1990-05-01)
Vitamin K deficiency has been reported in patients who were treated with antibiotics and placed on poor diets after surgery. High-performance liquid chromatography (HPLC) was used to study the influence of dietary intake on vitamin K concentrations in surgical patients

프로토콜

Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard

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