676950-M

Veratridine

≥98% (TLC), solid, Na⁺ channel opener, Calbiochem

• 동의어(들): Veratridine
• 실험식(Hill 표기법): C₃₆H₅₁NO₁₁
• CAS Number: 71-62-5
• Molecular Weight: 673.79
• MDL number: MFCD00082515
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• product name: Veratridine, A Na⁺ channel opener.
• Quality Level: 100
• 분석: ≥98% (TLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white to yellow
• solubility: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• 저장 온도: 2-8°C
• InChI: 1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
• InChI key: FVECELJHCSPHKY-YFUMOZOISA-N

설명

일반 설명

A Na⁺ channel opener. Increases intracellular Ca²⁺ levels without affecting Na⁺ - Ca²⁺ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na⁺ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

A Na⁺ channel opener. Increases intracellular Ca²⁺ levels without affecting Na⁺-Ca²⁺ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na⁺ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

생화학적/생리학적 작용

Primary Target
Na+ channel

경고

Toxicity: Highly Toxic (H)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Maroto, R., et al. 1994. Eur. J. Pharmacol. 270, 331.
Plattner, H., et al. 1994. J. Membr. Biol. 142, 229.
Rando, T.A., et al. 1989. J. Gen. Physiol.93, 43.
Rando, T.A., et al. 1986. Mol. Pharmacol.29, 467.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330,H315,H319,H335
• 예방조치 성명서: P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable