O3125

Ouabain octahydrate

≥95% (HPLC), powder

• 동의어(들): 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside), Acocantherine, G-Strophanthin
• 실험식(Hill 표기법): C₂₉H₄₄O₁₂ · 8H₂O
• CAS Number: 11018-89-6
• Molecular Weight: 728.77
• Beilstein: 101712
• EC Number: 211-139-3
• MDL number: MFCD00149240
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278610
• NACRES: NA.77

속성

• 생물학적 소스: plant seeds (Strophantus gratus)
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 형태: powder
• 광학 활성: [α]25/D −31 to −32.5° in H₂O(lit.)
• 불순물: ~8 mol/mol water
• 색상: white
• mp: 260 °C
• solubility: H₂O: 10 mg/mL (cold); ethanol: 10 mg/mL; H₂O: 50 mg/mL (hot)
• ε (흡광계수): 15.5 at 220 nm in H₂O at 1 mM
• 저장 온도: room temp
• SMILES string: O.O.O.O.O.O.O.O.C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O
• InChI: 1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-;;;;;;;;/m0......../s1
• InChI key: TYBARJRCFHUHSN-DMJRSANLSA-N
• 유전자 정보: human ... ATIC(471) ; rat ... Atp1b1(25650)

설명

일반 설명

Ouabain is a steroid hormone, naturally present in mammals.

애플리케이션

Ouabain octahydrate has been used:

• to determine the effect of salt and ammonia in the external environment on the rate of activity of Na⁺ /K⁺ in either silver or golden perch
• in the basolateral compartment to induce maximal baseline short-circuit current in rat fetal distal lung epithelial (FDLE) cells
• as an Na⁺/K⁺ ATPase inhibitor to study the relation between blister formation and adenosine triphosphate (ATP) dependent maintenance of plasma membrane homeostasis

생화학적/생리학적 작용

Cardiac glycoside, inhibits Na(+)/K(+) ATPase, regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity.

Ouabain has its specific binding site on integral proteins of the plasma membrane. Heart disease is treated using ouabain derivatives. Increased ouabain production is observed during exercise in humans. Abnormally high levels of ouabain are indicated in congestive heart failure and hypertension. Ouabain signalling affects intracellular calcium levels, which is known to activate nuclear factor κB (NFκB).

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

주의사항

Aqueous solutions can be autoclaved.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300,H331,H373
• 예방조치 성명서: P260 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3