D5891

1,1-Dimethyl-4-phenylpiperazinium iodide

≥98% (TLC or titration)

• 동의어(들): DMPP
• 실험식(Hill 표기법): C₁₂H₁₉IN₂
• CAS Number: 54-77-3
• Molecular Weight: 318.20
• Beilstein: 3746109
• EC Number: 200-213-0
• MDL number: MFCD00011976
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277832
• NACRES: NA.77

속성

• 분석: ≥98% (TLC or titration)
• 형태: powder
• mp: 234-238 °C (lit.)
• solubility: H₂O: 21 mg/mL
• 저장 온도: −20°C
• SMILES string: [I-].C[N+]1(C)CCN(CC1)c2ccccc2
• InChI: 1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
• InChI key: XFZJGFIKQCCLGK-UHFFFAOYSA-M
• 유전자 정보: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143) ; rat ... Chrna2(170945) , Chrna3(25101) , Chrna4(25590) , Chrnb2(54239) , Chrnb4(25103)

설명

애플리케이션

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:

• to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
• to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
• to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

생화학적/생리학적 작용

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves