539160

Proteasome Inhibitor I

The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): Proteasome Inhibitor I, PSI
• 실험식(Hill 표기법): C₃₂H₅₀N₄O₈
• Molecular Weight: 618.76
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥90% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMSO: 30 mg/mL; ethanol: 30 mg/mL; methanol: soluble
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α and Okadaic Acid (Cat. No. 495604) through inhibition of IκB-α degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available.

Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinylated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκB-α degradation, thereby interfering with induction of iNOS in macrophages.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells

Product does not compete with ATP.

Reversible: yes

경고

Toxicity: Standard Handling (A)

서열

Z-Ile-Glu(OtBu)-Ala-Leu-CHO

재구성

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

기타 정보

Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable