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Merck
모든 사진(1)

Key Documents

M8699

Sigma-Aldrich

(R)-MG132

동의어(들):

Z-L-Leu-D-Leu-L-Leu-al

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About This Item

실험식(Hill 표기법):
C26H41N3O5
CAS Number:
Molecular Weight:
475.62
UNSPSC 코드:
12352200
NACRES:
NA.32

분석

≥98%

Quality Level

solubility

DMSO or DMF: 25 mg/mL

저장 온도

−20°C

SMILES string

CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O

애플리케이션

(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.

생화학적/생리학적 작용

MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.

물리적 형태

crystalline solid or supercooled liquid

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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MG-132 is a tripeptide aldehyde (Z-l-leu-l-leu-l-leu-H, 2) proteasome inhibitor that exerts antitumor activity and enhances cytostatic/cytotoxic effects of chemo- and radiotherapy. Because of a troublesome synthesis of tripeptides with a non-natural configuration and modified side chains of amino acids, only

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