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C4859

Sigma-Aldrich

Cycloheximide solution

Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture

동의어(들):

CHX

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About This Item

실험식(Hill 표기법):
C15H23NO4
CAS Number:
66-81-9
Molecular Weight:
281.35
MDL number:
MFCD00082346
UNSPSC 코드:
12352111
PubChem Substance ID:
24892732
NACRES:
NA.77

생물학적 소스

microbial

Quality Level

300

설명

suitable for testing specifications (CHO C. growth inhibitor)

형태

solution

농도

100 mg/mL in DMSO

solubility

DMSO: soluble

항생제 활성 스펙트럼

fungi
yeast

동작 모드

protein synthesis | interferes

저장 온도

2-8°C

SMILES string

O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

유전자 정보

human ... FKBP1A(2280) , PIN1(5300)

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관련 카테고리

특이성

Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.

생화학적/생리학적 작용

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Hygroscopic. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H301,H315,H319,H341,H360D,H412

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

188.6 °F - closed cup

Flash Point (°C)

87 °C - closed cup

시험 성적서(COA)

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