추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in baculovirus infected Sf21 cells
분자량
Mw 67.3 kDa
제조업체/상표
Upstate®
기술
activity assay: suitable (kinase)
NCBI 수납 번호
UniProt 수납 번호
일반 설명
N-terminal GST-tagged recombinant human B-Raf residues 416-end, containing a V599E mutation (also designated V600E)
Product Source: Expressed by baculovirus in Sf21 insect cells
애플리케이션
Research Category
Inflammation & Immunology
Inflammation & Immunology
생화학적/생리학적 작용
Protein Target: B-Raf
Target Sub-Family: TKL
포장
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-557M when ordering the 250 µg size.
품질
routinely evaluated by phosphorylation of MBP substrate in vitro
물리적 형태
Glutathione agarose affinity chromatography
저장 및 안정성
6 months at -70°C
기타 정보
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Vanessa C Gray-Schopfer et al.
Cancer metastasis reviews, 24(1), 165-183 (2005-03-24)
Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. If detected early, it is easily treated by surgical excision. However, once melanoma metastasises it is notoriously resistant to
Mathew J Garnett et al.
Cancer cell, 6(4), 313-319 (2004-10-19)
RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform
Stevan R Hubbard
Cell, 116(6), 764-766 (2004-03-24)
A study by Wan et al. in this issue of Cell demonstrates that the majority of oncogenic mutations in the B-Raf protein kinase result in increased catalytic activity, through disruption of the autoinhibited state of the kinase domain. Surprisingly, several
Kathryn E Mercer et al.
Biochimica et biophysica acta, 1653(1), 25-40 (2003-06-05)
A recent report has shown that activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations represent a single nucleotide change
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