SAB4200593

Anti-Occludin antibody from rabbit

affinity isolated antibody

• 동의어(들): BLCPMG, OCLN, PPP1R115
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 종 반응성: human
• 기술: immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• UniProt 수납 번호: Q16625
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... OCLN(100506658)

설명

일반 설명

Occludin (OCLN) is an integral membrane protein, encoded by the gene mapped to human chromosome 5q13.2. OCLN is a ~65 kDa protein with four transmembrane domains including, a long COOH-terminal cytoplasmic domain, a short NH₂-terminal cytoplasmic domain, two extracellular loops, and one intracellular turn. It is specifically localized at tight junctions (TJ).

애플리케이션

Anti-Occludin antibody from rabbit has been used in immunocytochemistry and western blotting.

생화학적/생리학적 작용

Occludin (OCLN), along with tight junction (TJ)-associated peripheral membrane proteins, plays a vital role in formation and regulation of TJ. The encoded protein facilitates the translocation of p85a to TJs to regulate actin organization after oxidative stress. OCLN is also implicated in cell migration. Mutation in the gene leads to the development of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG).

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable