추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
195459 Da
종 반응성
human
기술
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TJP1(7082)
일반 설명
Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) is an adaptor protein. It acts as a scaffold protein between the tight junction and actin cytoskeleton. ZO1 has a molecular weight of 220kDa and is part of the membrane-associated guanylate kinase homolog family. The protein possesses three PDZ domains at its amino terminal, an SH3 domain and a region which bears homology to guanylate kinase. The ZO1 gene is localized on human chromosome 15q13.1.
애플리케이션
ANTI-ZO1(C-TERMINAL) antibody produced in rabbit has been used in immunofluorescence.
생화학적/생리학적 작용
Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) has a role in the formation of epithelial lumens. It interacts with occludin and modulates tight junction barrier regulation. ZO1 is also involved in the formation of the odontoblast layer and in actomyosin cytoskeleton regulation. Low expression of ZO1 has been linked to increased cell invasiveness in breast cancer, colorectal cancer and digestive tract cancers.
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Existence of Neural CresteDerived Progenitor
Cells in Normal and Fuchs Endothelial Dystrophy
Corneal Endothelium
Cells in Normal and Fuchs Endothelial Dystrophy
Corneal Endothelium
Kishore Reddy Katikireddy, et al.
The American Journal of Pathology (2016)
Increased ZO-1 expression predicts valuable prognosis in non-small cell lung cancer.
International Journal of Clinical and Experimental Pathology (2013)
The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks.
Van Itallie CM, et al.
Journal de Biologie Buccale (2013)
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
Tornavaca O, et al.
Journal of Cellular Biochemistry (2015)
Novel role of zonula occludens-1: A tight junction protein closely associated with the odontoblast differentiation of human dental pulp cells.
Xu J, et al.
Cell Biol. (2016)
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