04-147

Anti-ASC Antibody, clone 2EI-7

clone 2EI-7, from mouse

• 동의어(들): Caspase recruitment domain-containing protein 5, PYD and CARD domain containing, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, apoptosis-associated speck-like protein containing a CARD, caspase recruitment domain prot
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: 2EI-7, monoclonal
• 종 반응성: mouse
• 종 반응성(상동성에 의해 예측): human (based on 100% sequence homology)
• 기술: flow cytometry: suitable; western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NM_145182
• UniProt 수납 번호: Q9ULZ3
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PYCARD(29108)

설명

일반 설명

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Irregular expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.

특이성

This antibody recognizes ASC.

면역원

Epitope: Unknown

Full length recombinant human ASC.

애플리케이션

Detect ASC using this Anti-ASC Antibody, clone 2EI-7 validated for use in WB, FC.

Research Category
Inflammation & Immunology

Research Sub Category
Apoptosis - Additional

품질

Evaluated by Western Blot on mouse spleen tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected ASC in mouse spleen tissue lysate.

표적 설명

~22 kDa

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Mouse spleen tissue lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable