F3680

10058-F4

≥98% (HPLC), solid

• 동의어(들): 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
• 실험식(Hill 표기법): C₁₂H₁₁NOS₂
• CAS Number: 403811-55-2
• Molecular Weight: 249.35
• MDL number: MFCD00758517
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329799701
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: yellow
• solubility: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CCc1ccc(cc1)\C=C2\SC(=S)NC2=O
• InChI: 1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
• InChI key: SVXDHPADAXBMFB-JXMROGBWSA-N

설명

애플리케이션

10058-F4 has been used:

• as c-Myc inhibitor to treat stromal cells
• as c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growth
• as c-Myc inhibitor to culture T cells
• to treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct

생화학적/생리학적 작용

10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).

10058-F4 is a c-Myc inhibitor.

특징 및 장점

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317,H319
• 예방조치 성명서: P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves