475956
c-Myc Inhibitor
The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.
동의어(들):
c-Myc Inhibitor, 10058-F4, ( Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one, 10058-F4, (Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C12H11NOS2
CAS Number:
Molecular Weight:
249.35
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥95% (sum of two isomers, HPLC)
양식
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
yellow
solubility
DMSO: 200 mg/mL
배송 상태
ambient
저장 온도
2-8°C
InChI
1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
InChI key
SVXDHPADAXBMFB-JXMROGBWSA-N
일반 설명
A cell-permeable thiazolidinone compound that specifically inhibits the c-Myc-Max interaction, thereby preventing the transactivation of c-Myc target gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).
A cell-permeable, thiazolidinone compound that specifically inhibits c-Myc-Max interaction, thereby preventing the transactivation of c-Myc targeted gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (Effective concentration: 64 µM using c-Myc-transfected Rat1a fibroblasts).
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
c-Myc
c-Myc
Product does not compete with ATP.
Reversible: no
포장
Packaged under inert gas
경고
Toxicity: Carcinogenic / Teratogenic (D)
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Yin, X., et al. 2003. Oncogene22, 6151.
법적 정보
Sold under license of U.S. Patent 7,026,343.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Andrea Arena et al.
Biomedicines, 10(4) (2022-04-24)
Multiple myeloma (MM) and primary effusion lymphoma (PEL) are aggressive hematological cancers, for which the search for new and more effective therapies is needed. Both cancers overexpress c-Myc and are highly dependent on this proto-oncogene for their survival. Although c-Myc
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