Skip to Content
MilliporeSigma

PYCARD

PYD and CARD domain containing

Synonyms:
ASC, CARD5, TMS, TMS-1, TMS1
Species:
Human PYCARD (29108), Mouse Pycard (66824), Rat Pycard (282817), Zebrafish pycard (57923), dog PYCARD (489925), domestic cat PYCARD (101088449), cow PYCARD (282846), sheep PYCARD (101105208), Goat PYCARD (100861338), domestic guinea pig Pycard (100734858)
UniProtKB ID:
Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8
Gene ID:
  • Human(29108) Summary: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(66824) PYD and CARD domain containing
  • Rat(282817) PYD and CARD domain containing
  • Zebrafish(57923) PYD and CARD domain containing
  • dog(489925) PYD and CARD domain containing
  • domestic cat(101088449) PYD and CARD domain containing
  • cow(282846) PYD and CARD domain containing
  • sheep(101105208) PYD and CARD domain containing
  • Goat(100861338) PYD and CARD domain containing
  • domestic guinea pig(100734858) PYD and CARD domain containing

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
PRS2287
Anti-ASC antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunocytochemistry
immunohistochemistry
western blot
SAB4501315
Anti-ASC antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
SAB2500123
Anti-ASC/TMS1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
04-147
Anti-ASC Antibody, clone 2EI-7, clone 2EI-7, from mouse,
Species Reactivity
human, mouse
Application
flow cytometry
western blot
HPA049074
Anti-PYCARD antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
EHU066851
MISSION® esiRNA, targeting human PYCARD,
Species
human