추천 제품
Grade
certified reference material
형태
liquid
특징
Snap-N-Spike®/Snap-N-Shoot®
포장
ampule of 1 mL
제조업체/상표
Cerilliant®
농도
1.0 mg/mL in methanol
기술
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
응용 분야
clinical testing
형식
single component solution
저장 온도
2-8°C
SMILES string
OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
InChI
1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
InChI key
BHUYWUDMVCLHND-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
a-Hydroxytriazolam is a major urinary and blood metabolite of the benzodiazepine, triazolam, a pharmaceutical used to treat severe insomnia. This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.
애플리케이션
- Pharmacokinetic analysis of benzodiazepines: alpha-Hydroxytriazolam solution is employed in the quantitation of benzodiazepines and their metabolites in biological fluids using liquid chromatography-tandem mass spectrometry, providing accurate pharmacokinetic profiles that are essential for clinical and forensic analysis (Zheng et al., 2018).
- Receptor binding studies: The application of high-purity alpha-Hydroxytriazolam in receptor binding studies enables researchers to elucidate the interaction mechanisms of benzodiazepine analogs at the molecular level, thereby enhancing the understanding of their pharmacological effects (Minegishi et al., 2021).
- Development of analytical methods: alpha-Hydroxytriazolam solution serves as a critical analytical standard in the development of robust assays for the detection and quantification of benzodiazepines in various matrices, facilitating advancements in toxicological and pharmacological research (Lahr et al., 2020).
- Forensic and clinical toxicology: Utilized in forensic science, alpha-Hydroxytriazolam solution aids in the rapid determination of benzodiazepines and their metabolites in urine samples, crucial for the accurate interpretation of toxicological data (Jeong et al., 2015).
- Scientific research in biochemistry: alpha-Hydroxytriazolam research compounds are vital for studying the metabolic pathways and degradation profiles of triazolam and related benzodiazepines, supporting biochemists in drug metabolism and pharmacokinetics research (Jin et al., 2011).
법적 정보
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
표적 기관
Eyes,Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
49.5 °F - closed cup
Flash Point (°C)
9.7 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Qiran Sun et al.
Journal of analytical toxicology, 34(2), 89-94 (2010-03-13)
A sensitive liquid chromatography-tandem mass spectrometry method is presented for determination of triazolam and alpha-hydroxytriazolam in guinea pig hair after a single dose of triazolam. Eighteen guinea pigs were divided into three dosage groups (10, 100, and 500 microg/kg) and
F S Eberts et al.
Clinical pharmacology and therapeutics, 29(1), 81-93 (1981-01-01)
Triazolam (T) is a new, potent hypnotic with a short duration of action in man. After an 0.88-mg oral dose of T-14C in six male subjects, mean recovery of 14C radioactivity was 85% in urine and 8% in feces. The
Dong-Liang Lin et al.
Journal of analytical toxicology, 29(2), 118-123 (2005-05-21)
As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as
A D Fraser et al.
Journal of analytical toxicology, 16(6), 347-350 (1992-11-01)
Triazolam is a very short-acting triazolobenzodiazepine with sedative-hypnotic properties. Approximately 2% of an oral dose is excreted unchanged in the urine. The major urinary metabolite is alpha-hydroxytriazolam glucuronide (70% of the dose). The objective of this study was to characterize
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
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