902667

Propargyl-PEG6-acid

• 동의어(들): 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• 실험식(Hill 표기법): C₁₆H₂₈O₈
• CAS Number: 1951438-84-8
• Molecular Weight: 348.39
• MDL number: MFCD28950778
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• 분석: ≥95%
• 양식: liquid
• 반응 적합성: reaction type: click chemistry; reagent type: cross-linking reagent
• refractive index: n/D 1.469
• 작용기: alkyne; carboxylic acid
• 저장 온도: −20°C
• SMILES string: OC(CCOCCOCCOCCOCCOCCOCC#C)=O
• InChI: 1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18)
• InChI key: XRSJYQQOJNYUDV-UHFFFAOYSA-N

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable