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Merck

Exploring mechanisms of FGF signalling through the lens of structural biology.

Nature reviews. Molecular cell biology (2013-02-14)
Regina Goetz, Moosa Mohammadi
要旨

Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing and adult organism. The accumulated wealth of structural information on the FGF signalling pathway has begun to unveil the underlying molecular mechanisms that modulate this system to generate a myriad of distinct biological outputs in development, tissue homeostasis and metabolism. At the ligand and receptor level, these mechanisms include alternative splicing of the ligand (FGF8 subfamily) and the receptor (FGFR1-FGFR3), ligand homodimerization (FGF9 subfamily), site-specific proteolytic cleavage of the ligand (FGF23), and interaction of the ligand and the receptor with heparan sulphate cofactor and Klotho co-receptor.

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Sigma-Aldrich
β-グルクロニダーゼ from Helix pomatia, Type HP-2, aqueous solution, ≥100,000 units/mL
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, Type IX-A, lyophilized powder, 1,000,000-5,000,000 units/g protein (30 min assay)
Sigma-Aldrich
β-グルクロニダーゼ from Helix pomatia, Type H-2, aqueous solution, ≥85,000 units/mL
Sigma-Aldrich
β-グルクロニダーゼ from Helix pomatia, Type H-1, partially purified powder, ≥300,000 units/g solid
Sigma-Aldrich
β-グルクロニダーゼ from Helix pomatia, Type H-5, lyophilized powder, ≥400,000 units/g solid
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β-グルクロニダーゼ カサガイ(Patella vulgata)由来, Type L-II, lyophilized powder, 1,000,000-3,000,000 units/g solid
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β-グルクロニダーゼ from Helix pomatia, Type HP-2S, aqueous solution, ≥90,000 units/mL
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β-グルクロニダーゼ 大腸菌由来, Type VII-A, lyophilized powder, 5,000,000-20,000,000 units/g protein, pH 6.8 (30 min assay)
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β-グルクロニダーゼ ウシ肝臓由来, Type B-1, ≥1,000,000 units/g solid
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β-グルクロニダーゼ from Helix pomatia, Type H-3, aqueous solution, ≥90,000 units/mL
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, >20,000,000 units/g protein, recombinant, expressed in E. coli, aqueous glycerol solution
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, ≥20,000 units/mg protein, recombinant, expressed in E. coli overproducing strain, lyophilized powder
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, ≥10,000,000 units/g protein (30 min assay), recombinant, expressed in E. coli overproducing strain, lyophilized powder
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, aqueous glycerol solution, ≥5,000,000 units/g protein, pH 6.8 (biuret)
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β-グルクロニダーゼ ウシ肝臓由来, Type B-3, ≥2,000,000 units/g solid
Sigma-Aldrich
β-グルクロニダーゼ from Helix pomatia, Type H-3AF, aqueous solution, ≥60,000 units/mL
Sigma-Aldrich
β-グルクロニダーゼ Helix aspersa (プチグリ)由来, Type HA-4