WH0001641M1

Monoclonal Anti-DCX antibody produced in mouse

clone 1G12, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-DBCN, Anti-DC, Anti-LISX, Anti-SCLH, Anti-XLIS, Anti-doublecortex; lissencephaly, X-linked (doublecortin)
• MDL番号: MFCD03454961
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 1G12, monoclonal
• 形状: buffered aqueous solution
• 化学種の反応性: human
• テクニック: immunofluorescence: suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• アイソタイプ: IgG1κ
• GenBankアクセッション番号: BC027925
• UniProtアクセッション番号: O43602
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... DCX(1641)

詳細

詳細

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetyl hydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene. (provided by RefSeq) Doublecortin (DCX) is an essential gene for neurodevelopment and is expressed in neuronal progenitor cells and immature migrating neurons in the foetus. DCX is mapped to human chromosome Xq22.3-q23.

免疫原

DCX (AAH27925, 1 a.a. ~ 360 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSLDDSDSLGDSM

生物化学的／生理学的作用

Doublecortin (DCX) encodes a protein which binds to microtubule and is involved in neuronal migration through Ca²⁺ signalling. Mutations in DCX causes defect in neuronal migration, that results in lissencephaly (LIS) or smooth brain in males, and in females, it leads to subcortical laminar heterotopia (SCLH).LIS/SCLH leads to mental retardation or epilepsy.

物理的形状

Solution in phosphate buffered saline, pH 7.4

法的情報

GenBank is a registered trademark of United States Department of Health and Human Services

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)