DCX
doublecortin
Synonyms:
DBCN, DC, LISX, SCLH, XLIS
Species:
Human DCX (1641), Mouse Dcx (13193), Rat Dcx (84394), sheep DCX (101109861), naked mole-rat Dcx (101711611), domestic guinea pig Dcx (100713827), chicken DCX (374242), domestic cat DCX (494212), cow DCX (787968), Horse DCX (100058909)
UniProtKB ID:
Gene ID:
- Human(1641) Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
- Mouse(13193) doublecortin
- Rat(84394) doublecortin
- sheep(101109861) doublecortin
- naked mole-rat(101711611) doublecortin
- domestic guinea pig(100713827) doublecortin
- chicken(374242) doublecortin
- domestic cat(494212) doublecortin
- cow(787968) doublecortin
- Horse(100058909) doublecortin
- dog(612950) doublecortin
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DCX Antibody, clone 2G5, clone 2G5, from mouse,
Species Reactivity
human, mouse
Application
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Monoclonal Anti-DCX antibody produced in mouse, clone 1G12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Monoclonal Anti-DCX antibody produced in mouse, clone 3B7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-Doublecortin antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-DCX (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot