おすすめの製品
由来生物
human
品質水準
リコンビナント
expressed in E. coli
詳細
extracellular domain
アッセイ
≥98% (SDS-PAGE and HPLC)
フォーム
lyophilized powder
分子量
19.6 kDa
predicted mol wt ~21 kDa
テクニック
immunofluorescence: suitable
不純物
endotoxin, tested
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... TNFSF10(8743)
類似した製品をお探しですか？ 訪問 製品比較ガイド
関連するカテゴリー
アプリケーション
Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments. The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).
TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.
生物化学的／生理学的作用
TNFス-パ-ファミリ-の膜貫通タンパク質 II 型です。アポト-シスを誘導性デスレセプタ-のDR4, DR5、デコイレセプタ-のDcR1, DcR2、オステオプロテゲリンに対するリガンドです。FASリガンドとのアミノ酸配列の一致率は約28%です。ヒトTRAILとマウスTRAILとの配列の一致率は約65%です。
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.
TRAIL is a cytokine with anti-inflammatory, and antitumor activity. It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.
物理的形状
凍結乾燥品(PBS溶液)
アナリシスノート
The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T9701-10UG:
T9701-BULK:
T9701-20UG:
T9701-20UG-PW:
T9701-VAR:
この製品を見ている人はこちらもチェック
Lower maternal serum tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in early preeclampsia. A retrospective study
Morano D, et al.
Pregnancy hypertension, 12, 1-5 (2018)
Jan E Carette et al.
Nature biotechnology, 29(6), 542-546 (2011-05-31)
Insertional mutagenesis in a haploid background can disrupt gene function. We extend our earlier work by using a retroviral gene-trap vector to generate insertions in >98% of the genes expressed in a human cancer cell line that is haploid for
Melanoma antigen-D2: a nucleolar protein undergoing delocalization during cell cycle and after cellular stress
Pirlot C, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1863(4), 581-595 (2016)
Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells
Liu J, et al.
Clinical and Experimental Medicine, 1-13 (2018)
Fatih Birtekocak et al.
Iranian journal of pharmaceutical research : IJPR, 20(2), 45-56 (2021-09-28)
Colon cancer is one of the most prominent causes of cancer-related morbidity and mortality and curable if detected in the early stages. TNF-related apoptosis-inducing ligand (TRAIL) is a therapeutic protein and has a potential anti-cancer activity that is widely used
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）