T8276

抗TRPC1 ウサギ宿主抗体

affinity isolated antibody, lyophilized powder

• 別名: 抗一過性受容体電位陽イオンチャネル, サブファミリーC, メンバー1抗体
• MDL番号: MFCD02686004
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: lyophilized powder
• 化学種の反応性: rat
• テクニック: immunohistochemistry: suitable; western blot (chemiluminescent): suitable
• UniProtアクセッション番号: Q9QX01
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TRPC1(7220) ; mouse ... Trpc1(22063) ; rat ... Trpc1(89821)

詳細

詳細

Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.

免疫原

ヒトTRPC1(Genbank^®Accession No. P48995)のアミノ酸557-571に相当する合成ペプチド。エピトープはマウス、ラットと同一であり、ウシおよびアフリカツメガエル(Xenopus)と高い相同性があります。

生物化学的／生理学的作用

Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca²⁺ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.

物理的形状

凍結乾燥品 (0.3 mg/mLのPBS溶液, pH 7.4, 1%BSA, 5%スクロ-ス, 0.025%アジ化ナトリウム含有)。

法的情報

GenBank is a registered trademark of United States Department of Health and Human Services

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS06,GHS09
• シグナルワード: Danger
• 危険有害性情報: H301 + H311,H411
• 注意書き: P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P391 - P501
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2
• 補足的ハザード: EUH032
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges