T7154

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

• 別名: ラミニンフラグメント 929-933
• 実験式（ヒル表記法）: C₂₆H₄₂N₈O₈
• CAS番号: 110590-64-2
• 分子量: 594.66
• MDL番号: MFCD00076472
• UNSPSCコード: 12352209
• PubChem Substance ID: 24900419
• NACRES: NA.32

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥97% (HPLC)
• フォーム: powder
• テクニック: cell culture | mammalian: suitable
• 溶解性: H₂O: soluble 1 mg/mL, clear, colorless
• 保管温度: −20°C
• SMILES記法: CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1
• InChI Key: MWOGMBZGFFZBMK-LJZWMIMPSA-N

詳細

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

アプリケーション

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

生物化学的／生理学的作用

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.

Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

調製ノート

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)