T1455

TNP-470

≥98% (HPLC)

• 別名: (Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, AGM-1470, NSC 642492, O-Chloracetyl-carbamoyl fumagillol
• 実験式（ヒル表記法）: C₁₉H₂₈ClNO₆
• CAS番号: 129298-91-5
• 分子量: 401.88
• MDL番号: MFCD00870281
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826676
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 溶解性: DMSO: >15 mg/mL
• オーガナイザー: Takeda
• 保管温度: −20°C
• SMILES記法: CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@@]3(C)O[C@@H]3C\C=C(\C)C)OC(=O)NC(=O)CCl
• InChI: 1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
• InChI Key: MSHZHSPISPJWHW-PVDLLORBSA-N

詳細

詳細

TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.

生物化学的／生理学的作用

TNP-470はメチオニンアミノペプチダーゼ-2(MetAP-2)インヒビターであり、MetAP11よりもMetAP-2に対して選択的です。TNP-470は、抗血管新生作用を有します。

Studies have reported that TNP-470 can decrease intimal neovascularization in Apo-E deficient mice. TNP-470 can also prevent tumor growth in human breast and prostate cancer cell lines.

特徴および利点

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

調製ノート

TNP-470 is soluble in DMSO at a concentration that is greater than 15 mg/ml.

その他情報

TNP-470には吸湿性があります。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable