SRP8056

Tim-3 (mouse): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 別名: HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIM3, TIMD3
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: mouse
• リコンビナント: expressed in CHO cells
• アッセイ: ≥98% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: monomer 45 kDa by calculation
• 包装: pkg of 100 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: <0.06 EU/μg endotoxin, tested
• 色: white
• UniProtアクセッション番号: Q8VIM0
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: mouse ... Havcr2(171285)

詳細

詳細

Tim-3 is a type I transmembrane protein. It contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Type 1 T-helper (Th1) and Type 1 CD8⁺ T (Tc1) cells. TIM-3 is also expressed on some dendritic cells. The gene encoding this protein is localized on mouse chromosome 11B1.1.

生物化学的／生理学的作用

The T cell/transmembrane, immunoglobulin and mucin (TIM) family plays a crucial role in regulating immune responses, such as allergy, asthma, transplant tolerance, autoimmunity and also has a control over the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 generates an inhibitory signal resulting in apoptosis of Type 1 T-helper (Th1) and Type 1 CD8⁺ T (Tc1) cells. It can also mediate phagocytosis of apoptotic cells and cross-presentation of antigen. It functions to inhibit aggressive Th1-mediated auto- and allo-immune responses. Tim-3 pathway blockade by administration of Tim-3: Fc fusion protein accelerates diabetes in non-obese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

物理的形状

Lyophilized from 0.2 μm-filtered solution in PBS.

再構成

Reconstitute at 100 μg/mL in sterile PBS.

その他情報

The extracellular domain of mouse Tim-3 (aa 21-189) is fused to the N-terminus of the Fc region of human IgG1.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable