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詳細
α 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a “trap” method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half-life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17–0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer′s disease and spongiform encephalopathy.
α 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg/100 mL in men and 290 mg/100 mL in women. It is produced by the liver and is a major component of the α-2 band in protein electrophoresis. It has a molecular weight of 800,000Da.
生物化学的／生理学的作用
α 2 macroglobulin (A2M) functions as a broad-spectrum protease-binding protein. In addition, it acts as an irreversible inhibitor of a variety of proteinases. A2M expressed in the brain interacts with multiple extracellular ligands and is interiorized by neurons and astrocytes. In the brain of Alzheimer′s disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M interacts with soluble β-amyloid and facilitates its degradation.
物理的形状
Lyophilized from 100 mM Na Phosphate, pH 7.2.
再構成
In water or aqueous buffer
保管分類コード
13 - Non Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP6315-1MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Interleukin-6 and α2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.
Bauer, Joachim, et al.
Febs Letters, 285(1), 111-114 (1991)
The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.
Barrett A J and Phyllis M S
The Biochemical Journal, 133(4), 709-724 (1973)
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