SRP6302

アポリポプロテイン B ヒト血漿由来

≥95% (SDS-PAGE)

• 別名: Apo-B
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human plasma
• アッセイ: ≥95% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: 550 kDa
• 包装: pkg of 500 μg
• UniProtアクセッション番号: P04114
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... ApoB(338)

詳細

詳細

Apolipoprotein B is the dominant protein constituent of low-density lipoprotein (LDL). The concentration of Apo B in normal plasma is 90mg/100mL. Two forms of Apo B exist: Apo B-100 and Apo B-48. The first is found in VLDL and LDL and is produced by the liver. The second is found in chylomicrons and originates in the intestine. The gene encoding this protein is localized on chromosome 2p24.1.

生物化学的／生理学的作用

Apo B is thought to stabilize lipid emulsions, serve as a cofactor and modulator of enzymatic reactions, manage export of lipids out of cells and direct lipids to target organs. Apo B levels are positively correlated with the risk of coronary disease. Apo B levels may be a more sensitive predictor of cardiovascular risk than LDL levels and do not involve fasting for accurate measurement. Mutations in this gene or its regulatory region cause hypoβ-lipoproteinemia, normotriglyceridemic and hypercholesterolemia due to ligand-defective ApoB, diseases affecting plasma cholesterol and ApoB levels.

物理的形状

Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCI.

再構成

In water or aqueous buffer

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable