SRP5218

EIF2AK4 (192-1024)、活性型、GSTタグ融合 ヒト

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 別名: GCN2, KIAA1338
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• リコンビナント: expressed in baculovirus infected Sf9 cells
• 製品種目: PRECISIO^® Kinase
• アッセイ: ≥70% (SDS-PAGE)
• 形状: buffered aqueous glycerol solution
• 比活性: 11.9-16.1 nmol/min·mg
• 分子量: ~132 kDa
• NCBIアクセッション番号: NM_001013703
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... EIF2AK4(440275)

詳細

詳細

Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4), also known as GCN2 is an enzyme encoded by EIF2AK4 gene in humans. In mouse, EIF2AK4 is widely expressed with prominent expression in liver and brain.

生物化学的／生理学的作用

Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4) is responsible for phosphorylation of the a subunit of the eukaryotic initiation factor 2 (eIF2α). The EIF2AK4 eIF2-α kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. The protein p58IPK inhibits EIF2AK4 activity. EIF2AK4 is linked to pulmonary veno-occlusive disease (PVOD) development and its pathway is associated with diseases such as cancer and Alzheimer′s disease. The protein affects many aspects of cellular physiology in response to a number of stresses such as starvation. Mutation in EIF2AK4 may cause autosomal-recessive pulmonary capillary hemangiomatosis (PCH). EIF2AK4 causes tumor growth and angiogenesis by expression of vascular endothelial growth factor (VEGF).

物理的形状

50 mM Tris-HCl(pH 7.5, 150 mM NaCl, 10 mMグルタチオン, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25%グリセロール含有)を用いた溶液として調製されています。

調製ノート

開封後はそれぞれの目的に応じて少量ずつ分注し、-70°Cで保存してください。また、取扱いや凍結融解について、繰り返しのご使用は避けてください。

法的情報

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable