SML4014

Edrophonium chloride

≥98% (HPLC)

• 別名: Dimethylethyl(3-hydroxyphenyl)ammonium chloride, Edrophone chloride, Ethyl(m-hydroxyphenyl)dimethylammonium chloride, N-Ethyl-3-hydroxy-N,N-dimethyl-benzenaminium chloride
• 実験式（ヒル表記法）: C₁₀H₁₆NO·Cl
• CAS番号: 116-38-1
• 分子量: 201.69
• MDL番号: MFCD00055064
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: , Faint brown to very dark red brown
• 溶解性: DMSO: 2 mg/mL, clear (Warmed)
• 保管温度: room temp
• SMILES記法: OC1=CC=CC([N+](CC)(C)C)=C1.[Cl-]
• InChI: 1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
• InChI Key: BXKDSDJJOVIHMX-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Bioavailable, acetylcholinesterase inhibitor with rapid onset and short duration of action.



Edrophonium chloride is a fast-acting, reversible and competitive inhibitor of acetylcholinesterase (AChE; Ki = 0.2, 0.2, and 0.4 μM in human red blood cells, purified calf forebrain, and octopus brain, respectively) with no effect on butyrylcholinesterase (BChE) activity. Edrophonium dispensing increases acetylcholine (ACh) levels in the neuromuscular junction to result in brief improvements in skeletal and muscular strength. Allosterically interacts with AChE-Serine103 and has a rapid onset of action occurring within 1 minute of administration and a short duration of action lasting 10 minutes with a very short half-life of 2–5 min (intravenous). Atropine, a competitive inhibitor of muscarinic receptors, is an ideal antidote for edrophonium.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable