SML3881

AK-2292

≥98% (HPLC)

• 別名: ((2-(((2S)-1-((2S)-2-((3-((5-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)(methyl)amino)-3-oxopropyl)(4-(thiazol-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)benzo[b]thiophen-5-yl)difluoromethyl)phosphonic acid
• 実験式（ヒル表記法）: C₅₂H₅₄F₂N₇O₁₀PS₂
• CAS番号: 2984506-77-4
• 分子量: 1070.13
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C

詳細

生物化学的／生理学的作用

Cell penetrant, potent and highly selective degrader of STAT5A and STAT5B isoforms.


AK-2292 is a cell penetrant, potent and highly selective PROTAC degrader of STAT5A (signal transducer and activator of transcription 5 A) and STAT5B isoforms. AK-2292 potently induces degradation of STAT5 in normal mouse tissues and human chronic myeloid leukemia (CML) xenografts in mice. It potently inhibits the growth of acute myeloid leukemia (AML) cell lines.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable