SML3718

SIAIS630121

≥98% (HPLC)

• 別名: (E)-N-(4-(1-(4-(4-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-yn-1-yl)piperazin-1-yl)benzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
• 実験式（ヒル表記法）: C₄₉H₅₉N₇O₅
• 分子量: 826.04
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (Warmed)
• 保管温度: -10 to -25°C
• SMILES記法: O=C(/C=C/C1=CN=CC=C1)NCCCCC2CCN(CC2)C(C3=CC=C(C=C3)N4CCN(CC4)CCCCCCC#CC5=CC=CC6=C5CN(C6=O)C7C(NC(CC7)=O)=O)=O
• InChI: 1S/C49H59N7O5/c57-45(22-16-38-12-10-26-50-35-38)51-27-7-6-11-37-24-29-55(30-25-37)48(60)40-17-19-41(20-18-40)54-33-31-53(32-34-54)28-8-4-2-1-3-5-13-39-14-9-15-42-43(39)36-56(49(42)61)44-21-23-46(58)52-47(44)59/h9-10,12,14-20,22,26,35,37,44H,1-4,6-8,11,21,
• InChI Key: JTTGVFCANBFLCE-CJLVFECKSA-N

詳細

生物化学的／生理学的作用

Orally available, cell penetrant, potent and highly selective PROTAC that induces NAMPT degradation in several cancer cells lines

SIAIS630121 is an orally available, cell penetrant, potent and highly selective proteolysis-targeting chimera (PROTAC) that induces NAMPT (nicotinamide phosphoribosyltransferase) degradation in several cancer cells lines (SW620, HT29, and HCT116). It contains NAMPT inhibitor FK866 linked to cereblon (CRBN) ligand lenalidomide. SIAIS630121 exhibits rapid and potent degradation of iNAMPT and eNAMPT.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable