SML3456

LUF7244

≥98% (HPLC)

• 別名: 2-​[4-​(3-​Chlorobenzoyl)​phenoxy]​-​N-​3-​pyridinyl-acetamide
• 実験式（ヒル表記法）: C₂₀H₁₅ClN₂O₃
• CAS番号: 1821638-43-0
• 分子量: 366.80
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: O=C(NC1=CC=CN=C1)COC2=CC=C(C=C2)C(C3=CC=CC(Cl)=C3)=O

詳細

生物化学的／生理学的作用

LUF7244 is a potent and selective voltage-gated potassium 11.1 (Kv11.1) channels negative allosteric modulator/activator that inhibits early afterdepolarizations in vitro. It decreases the affinity of Kv11.1 for cisapride, astemizole, dofetilide and sertindole. LUF7244 averts dofetilide‐induced torsades de pointes arrhythmias in dogs with chronic atrioventricular block. LUF7244 in combination with dofetilide rescues both congenital and acquired Kv11.1 trafficking defects and produces functional Kv11.1 current in trafficking defective G601S-Kv11.1 cells.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable