SML3357

Rasarfin

≥98% (HPLC)

• 別名: N-(3-Chloro-4-(4-isobutyrylpiperazin-1-yl)phenyl)benzofuran-2-carboxamide, N-[3-Chloro-4-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]-2-benzofurancarboxamide
• 実験式（ヒル表記法）: C₂₃H₂₄ClN₃O₃
• CAS番号: 674359-73-0
• 分子量: 425.91
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (Warmed)
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=C(N4CCN(CC4)C(C(C)C)=O)C(Cl)=C3

詳細

生物化学的／生理学的作用

Rasarfin is a dual Ras and ARF6 inhibitor that inhibits both receptor internalization and signaling. It blocks agonist-mediated internalization of AT1R and other GPCRs. Rasarfin potently inhibits agonist induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR. It prevents cancer cell proliferation.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable