SML3306

BAY-390

≥98% (HPLC)

• 別名: (1R,2R)-2-(4-Fluorophenylamino)-1-(trifluoromethyl)cyclohexanol, BAY 390, BAY390
• 実験式（ヒル表記法）: C₁₃H₁₅F₄NO
• CAS番号: 2741956-55-6
• 分子量: 277.26
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: oil
• 色: yellow to orange
• 保管温度: 2-8°C
• SMILES記法: FC1=CC=C(C=C1)N[C@H]2[C@@](C(F)(F)F)(CCCC2)O

詳細

生物化学的／生理学的作用

BAY-390 is an orally active, potent and selective TRPA1 inhibitor (cellular Ca++ influx IC50 in nM by FLIPR = 16/hu, 19/monkey, 63/rat, 68/guinea pig, 73/mu, 81/dog; IC50 = 5.6 µM/hTRPC5, >25 µM/human TRPV1/4, TRPC3/6, KCNK9 (TASK-3), CACNA1H (Cav3.2)) that shows in vivo efficacy in animal models of inflammatory pain (30 or 90 mg/kg mice, p.o.) and neurogenic pain (30 or 90 mg/kg rats, b.i.d. p.o.).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable