SML3287

Sulfopin

≥98% (HPLC)

• 別名: 2-Chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-acetamide
• 実験式（ヒル表記法）: C₁₁H₂₀ClNO₃S
• CAS番号: 2451481-08-4
• 分子量: 281.80
• MDL番号: MFCD32860123
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: [S]1(=O)(=O)CC(CC1)N(CC(C)(C)C)C(=O)CCl
• InChI: 1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3
• InChI Key: NMHVAHHYKGXBMY-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

In vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1)

Sulfopin is an in vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) that binds to active site Cys113. Sulfopin induces downregulation of c-Myc target genes, inhibits tumor progression. It extends survival in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable