SML3200

MK-0608

≥98% (HPLC)

• 別名: 2′-C-Methyl-7-deaza-adenosine, 4-Amino-7-(2-C-methyl-[beta]-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine, 7′DMA, 7-(2-C -Methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d ]pyrimidin-4-amine, 7-DMA, 7-Deaza-2’-C-methyladenosine, 7-Deaza-2’-CMA, 7DMA, MK 0608, MK 608, MK-608, MK0608, MK608
• 実験式（ヒル表記法）: C₁₂H₁₆N₄O₄
• CAS番号: 443642-29-3
• 分子量: 280.28
• MDL番号: MFCD14584964
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 光学活性: [α]/D -155 to -185°, c = 1 in methanol
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: [n]2(c3ncnc(c3cc2)N)[C@@H]1O[C@@H]([C@H]([C@]1(O)C)O)CO
• InChI: 1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1
• InChI Key: IRZRJANZDIOOIF-GAJNKVMBSA-N

詳細

生物化学的／生理学的作用

MK-0608 (7DMA; 2′-C-Methyl-7-deaza-adenosine; 7-Deaza-2′-C-methyladenosine) is an orally active antiviral nucleoside analog that inhibits hepatitis C virus (HCV genotype 1b replicon IC50/90 = 0.3/1.3 ?M) and Zika virus (ZIKV strain MR766 IC50 = 1.3-9.6 μM) replication by targeting viral RNA-dependent RNA polymerase. MK-0608 effectively reduces viral load in HCV-infected (0.2-2 mg/kg chimpanzees via daily i.v. or p.o.; 3-50 mg/kg mice b.i.s. p.o.) and ZIKV-infected animals in vivo (50 mg/kg mice via daily p.o.).

Orally active antiviral nucleoside analog that inhibits hepatitis C virus (HCV) and Zika virus (ZIKV) replication in vitro and in vivo.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable