SML2597

Etravirine

≥98% (HPLC)

• 別名: 4-((6-Amino-5-bromo-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile, 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile, 4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile, TMC125
• 実験式（ヒル表記法）: C₂₀H₁₅BrN₆O
• CAS番号: 269055-15-4
• 分子量: 435.28
• MDL番号: MFCD09837879
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: Brc1c(nc(nc1Oc3c(cc(cc3C)C#N)C)Nc2ccc(cc2)C#N)N
• InChI: 1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)
• InChI Key: PYGWGZALEOIKDF-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Etravirine is a second-generation Nonnucleoside reverse transcriptase inhibitor (NNRTI) anti-retroviral. It is active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for efavirenz and Y181C for nevirapine.

安全性情報

• ピクトグラム: GHS09
• シグナルワード: Warning
• 危険有害性情報: H410
• 注意書き: P273
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable