SML2272

AZD-2098

≥98% (HPLC)

• 別名: 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide, 2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide, AZD 2098, AZD2098
• 実験式（ヒル表記法）: C₁₁H₉Cl₂N₃O₃S
• CAS番号: 566203-88-1
• 分子量: 334.18
• MDL番号: MFCD31382158
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O

詳細

生物化学的／生理学的作用

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ∼120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable