SML2152

10Panx1 trifluoroacetate salt

≥98% (HPLC)

• 別名: 10Panx trifluoroacetate salt, Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr trifluoroacetate salt, WRQAAFVDSY trifluoroacetate salt
• 実験式（ヒル表記法）: C₅₈H₇₉N₁₅O₁₆ · xC₂HF₃O₂
• CAS番号: 955091-53-9
• 分子量: 1242.34 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: film
• 色: white to beige
• 輸送温度: wet ice
• 保管温度: −20°C
• InChI: 1S/C58H79N15O16/c1-29(2)47(56(87)70-42(26-46(77)78)53(84)72-44(28-74)55(86)71-43(57(88)89)24-33-16-18-35(75)19-17-33)73-54(85)41(23-32-11-6-5-7-12-32)69-49(80)31(4)65-48(79)30(3)66-51(82)40(20-21-45(60)76)68-52(83)39(15-10-22-63-58(61)62)67-50(81)37(59)25-34-27-64-38-14-9-8-13-36(34)38/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,79)(H,66,82)(H,67,81)(H,68,83)(H,69,80)(H,70,87)(H,71,86)(H,72,84)(H,73,85)(H,77,78)(H,88,89)(H4,61,62,63)/t30-,31-,37-,39-,40-,41-,42-,43-,44-,47-/m0/s1
• InChI Key: JCJASTVQGSKHKZ-QZHJRRRASA-N

詳細

アプリケーション

10Panx1 trifluoroacetate salt has been used as the selective pannexin-1 mimetic inhibitory peptide to study the involvement of pannexin-1 in praliciguat (PRL) inhibition of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome.

生物化学的／生理学的作用

The pannexin-1 (panx1) extracellular sequence-derived 10panx1 functions as a reversible panx1 channel blocker (IC50 = 52 μM; human panx1-overexpressing HEK cells) that effectively inhibits ATP-induced dye-uptake in panx1 HEK cells co-expressing rat or human P2X7R (IC50 = 93 μM), as well as in murine J774 and human alveolar macrophages (Effective conc. 100-200 μM). 10panx1 (100 μM) is shown to protect rat hippocampal neurons against death induction upon NMDAR overactivation by excitotoxic concentrations of NMDA (100 μM) in cultures and ameliorate withdrawal symptoms among morphine-treated rats in vivo (10 μg/rat via intrathecal injection).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable