SML1929

Equisetin

(Fusarium equiseti), ≥97% (HPLC)

• 別名: (3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione
• 実験式（ヒル表記法）: C₂₂H₃₁NO₄
• CAS番号: 57749-43-6
• 分子量: 373.49
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 200
• 由来生物: (Fusarium equiseti)
• アッセイ: ≥97% (HPLC)
• 形状: powder
• 溶解性: DMSO: soluble 1 mg/mL; chloroform: soluble 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: C[C@H]1C[C@]2([H])[C@@]([C@](C)(/C(O)=C3C([C@H](CO)N(C)C/3=O)=O)[C@H](/C=C/C)C=C2)([H])CC1
• InChI: 1S/C22H31NO4/c1-5-6-15-9-8-14-11-13(2)7-10-16(14)22(15,3)20(26)18-19(25)17(12-24)23(4)21(18)27/h5-6,8-9,13-17,24,27H,7,10-12H2,1-4H3/b6-5+/t13-,14-,15-,16-,17+,22-/m1/s1
• InChI Key: SLOQQJFOWFUUMP-KNQICWOTSA-N

詳細

生物化学的／生理学的作用

Equisetin is a tetramic acid analog derived from Fusarium equisti. Equisetin is mainly known for its antibiotic and cytotoxic activity and for its inhibitory effect on HIV-1 integrase. Inhibition of HIV integrase by Equisetin was reported with IC₅₀ values of 5-20 μM. Moreover, it was shown that Equisetin specifically inhibits the substrate anion carriers of the inner membrane of mitochondria and acts nonspecifically on protein membranes and protein hydrophobic domains. In addition, it was demonstrated that Equisetin causes phytotoxicity by causing root Necrosis and was also identified in a mycotoxin cocktail associated with cattle feeding problems.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable