SML1455
DAA-I acetate salt
≥98% (HPLC)
別名:
5-L-Isoleucine-2-10-Angiotensin I acetate salt, Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu acetate, RVYIHPFHL acetate, [Des-Asp1-Ile5]angiotensin I, des-Asp-angiotensin I acetate, des-aspartate-angiotensin-I acetate
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About This Item
実験式（ヒル表記法）:
C58H84N16O11 · xC2H4O2
CAS番号:
分子量:
1181.39 (free base basis)
UNSPSCコード:
12352200
NACRES:
NA.77
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生物化学的／生理学的作用
DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor and releases prostaglandins which mediate its actions. DAA-I administer at doses lesser than Km of metabolizing enzymes antagonize the deleterious actions of angiotensin II. DAA-I appear function in vivo as a physiological antagonist to angiotensin II.
Des-aspartate-angiotensin I (DAA-I) is a nine-amino acid angiotensin peptide and a metabolite of angiotensin DAA-I mediates attenuation of early inflammatory processes and intercellular adhesion molecule-1 (ICAM-1) formation in animal models.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
M Dharmani et al.
Regulatory peptides, 129(1-3), 213-219 (2005-06-02)
The present study investigated the action of des-aspartate-angiotensin I (DAA-I) on the pressor action of angiotensin II in the renal and mesenteric vasculature of WKY, SHR and streptozotocin (STZ)-induced diabetic rats. Angiotensin II-induced a dose-dependent pressor response in the renal
Ko-Onn Lee et al.
Drugs in R&D, 16(4), 317-326 (2016-09-30)
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT
Hong Wang et al.
PloS one, 10(9), e0138009-e0138009 (2015-09-18)
ACE inhibitors and ARBs (angiotensin receptor blockers) have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathways that are up-regulated during
M R Mustafa et al.
Regulatory peptides, 120(1-3), 15-22 (2004-06-05)
An earlier study showed that des-aspartate-angiotensin I (DAA-I) attenuated the pressor action of angiotensin III in aortic rings of the spontaneously hypertensive rat (SHR) but not the normotensive Wistar Kyoto (WKY) rat. The present study investigated similar properties of DAA-I
Meng-Kwoon Sim et al.
Regulatory peptides, 188, 40-45 (2013-12-18)
L6 skeletal muscle cells overexpressed ICAM-1 when treated with H2O2. Maximum effect was observed at 200 μM H2O2. Des-aspartate-angiotensin I (DAA-I) concentration-dependently attenuated the overexpression. Maximum attenuation occurred at 10(-10) M DAA-I. H2O2 activated NFκB and its translocation into the
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