SML1427

AZ3146

≥98% (HPLC)

• 別名: 9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one, AZ-3146
• 実験式（ヒル表記法）: C₂₄H₃₂N₆O₃
• CAS番号: 1124329-14-1
• 分子量: 452.55
• MDL番号: MFCD18384959
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825868
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to light brown
• 溶解性: DMSO: 2 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: CN1CCC(OC2=CC(OC)=C(NC3=NC=C4C(N(C5CCCC5)C(N4C)=O)=N3)C=C2)CC1
• InChI: 1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
• InChI Key: YUKWVHPTFRQHMF-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC₅₀ = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable