SML1278

Geldanamycin Ready Made Solution

1 mg/mL, from Streptomyces hygroscopicus

• 別名: 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
• 実験式（ヒル表記法）: C₂₉H₄₀N₂O₉
• CAS番号: 30562-34-6
• 分子量: 560.64
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: Streptomyces hygroscopicus
• 品質水準: 200
• 形状: DMSO solution
• 保管条件: protect from light
• 濃度: 1 mg/mL
• 抗生物質活性スペクトル: neoplastics
• 作用機序: enzyme | inhibits
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• InChI Key: QTQAWLPCGQOSGP-KSRBKZBZSA-N

詳細

詳細

Chemical structure: benzenoid

アプリケーション

Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

生物化学的／生理学的作用

Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F
• 引火点(℃): 87 °C