SML1058

PBIT

≥98% (HPLC)

• 別名: 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one, 2-p-Tolyl-1,2-benzisothiazolin-3-one
• 実験式（ヒル表記法）: C₁₄H₁₁NOS
• CAS番号: 2514-30-9
• 分子量: 241.31
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: [s]1[n]([c](c3c1cccc3)=O)c2ccc(cc2)C
• InChI: 1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
• InChI Key: KRXMYBAZKJBJAB-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

S,S′-1,4-phenylenebis(1,2-ethanediyl)bis-isothiourea (PBIT) is an iNOS (inducible nitric oxide synthase) inhibito. It is capable of inhibiting the multiplication of breast cancer cell lines expressing high levels of JARIDB1.

PBIT is a potent inhibitor of JARID1B (KDM5B) histone lysine demethylase that inhibits removal of H3K4me3 in UACC-812 cells. PBIT inhibits proliferation of cells overexpressing JARID1B. PBIT is selective for JARID1 enzymes and does not inhibit demethylases UTX or JMJD3.

PBIT is a potent inhibitor of JARID1B (KDM5B).

特徴および利点

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable