SML1018

Cyclosporin A

≥95% (HPLC), DMSO solution, calcineurin inhibitor

• 別名: シクロスポリン
• 実験式（ヒル表記法）: C₆₂H₁₁₁N₁₁O₁₂
• CAS番号: 59865-13-3
• 分子量: 1202.61
• EC Number: 200-664-3
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: Cyclosporin A, Ready Made Solution, 1 mg/mL in DMSO
• 形状: DMSO solution
• 品質水準: 200
• 保管条件: protect from light
• 濃度: 1 mg/mL in DMSO
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
• InChI Key: PMATZTZNYRCHOR-IMVLJIQESA-N

詳細

アプリケーション

Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model.

生物化学的／生理学的作用

Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca²⁺- and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes. At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin. CsA can inhibit IL₂ production resulting from T cell activation via Calcineurin inhibition.
An extensive list of references has been reported, including a comprehensive review of analytical properties.

Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects.

その他情報

Light sensitive

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup
• 引火点(℃): 87 °C - closed cup