SML0522

JM6

≥97% (HPLC)

• 別名: 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide
• 実験式（ヒル表記法）: C₂₃H₂₆N₄O₆S₂
• CAS番号: 1008119-83-2
• 分子量: 518.61
• MDL番号: MFCD22380618
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825529
• NACRES: NA.77

特性

• アッセイ: ≥97% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL (clear solution, warmed)
• 保管温度: 2-8°C
• SMILES記法: COc1ccc(cc1OC)S(=O)(=O)Nc2nc(c(CN3CCCCC3)s2)-c4cccc(c4)[N+]([O-])=O
• InChI: 1S/C23H26N4O6S2/c1-32-19-10-9-18(14-20(19)33-2)35(30,31)25-23-24-22(16-7-6-8-17(13-16)27(28)29)21(34-23)15-26-11-4-3-5-12-26/h6-10,13-14H,3-5,11-12,15H2,1-2H3,(H,24,25)
• InChI Key: AOZLMMDVJOGGEQ-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain. JM6 prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease.

特徴および利点

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable