SML0508

Pentostatin

≥95% (HPLC)

• 別名: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin
• 実験式（ヒル表記法）: C₁₁H₁₆N₄O₄
• CAS番号: 53910-25-1
• 分子量: 268.27
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825517
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 光学活性: [α]/D +70 to +80°, c = 1 in H₂O
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 10 mg/mL, clear
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23
• InChI: 1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
• InChI Key: FPVKHBSQESCIEP-JQCXWYLXSA-N
• 遺伝子情報: human ... ADA(100)

詳細

アプリケーション

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

生物化学的／生理学的作用

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).

Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.

特徴および利点

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

その他情報

Air sensitve; hygroscopic.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable