おすすめの製品
品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to light brown
溶解性
DMSO: 15 mg/mL, clear
保管温度
2-8°C
SMILES記法
Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23
InChI
1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChI Key
SEDUMQWZEOMXSO-UHFFFAOYSA-N
アプリケーション
SB265610 has been used:
- as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR)
- as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells
- as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain
生物化学的／生理学的作用
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
特徴および利点
This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
毒物及び劇物取締法
劇物
Jan Code
SML0421-5MG:4548173909158
SML0421-25MG:4548173909141
SML0421-VAR:
SML0421-BULK:
最新バージョンのいずれかを選択してください：
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資料
Sigma-Aldrich offers many products related to chemokine receptors for your research needs.
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