239819

CXCR2 antagonist, Cpd 19

The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.

• 別名: CXCR2 antagonist, Cpd 19, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
• 実験式（ヒル表記法）: C₁₈H₂₁N₃O₄
• CAS番号: 473728-67-5
• 分子量: 343.38
• UNSPSCコード: 12352200
• NACRES: NA.51

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 50 mg/mL, light brown
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC₅₀ = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC₅₀ = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37^°C).

包装

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable