227016

CCR2 Antagonist

≥97% (racemic mixture, HPLC), solid, CCR2 antagonist, Calbiochem^®

• 別名: CCR2 Antagonist, 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
• 実験式（ヒル表記法）: C₂₈H₃₄F₃N₅O₄S
• CAS番号: 445479-97-0
• 分子量: 593.66
• MDL番号: MFCD00133899
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: CCR2 Antagonist, The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
• 品質水準: 100
• アッセイ: ≥97% (racemic mixture, HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: ethanol: 6 mg/mL; DMSO: 60 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC₅₀ = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca⁺² flux and chemotaxis (IC₅₀ = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

調製ノート

Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Cherney, R.J., et al. 2008. J. Med. Chem.51, 721.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable